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Thyroglobulin is then exocytosed by way of the apical membrane into the closed lumen of thyroid follicles (the colloid), the place it accumulates as the major protein of the thyroid gland and where maturation takes place. Within the colloid iodide (I – ) is oxidized to I + by thyroid peroxidase (TPO; also referred to as thyroperoxidase) discovered only in thyroid tissue. The TPO gene is situated on chromosome 2p25. Mutations in the TPO gene are related to a number of issues of thyroid hormone biogenesis which includes congenital hypothyroidism, thyroid hormone organification defect IIA, and congenital goiter, what is the best supplement to increase height. The oxidation reaction catalyzed by TPO requires hydrogen peroxide (H 2 O 2 ) which is produced by an NADPH oxidase advanced sometimes called thyroid oxidase.
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